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Neurophysiologic Signatures of Trigeminal Neuralgia Pain

July 24, 2019

Overview

 

The Neurophysiologic Signatures of Trigeminal Neuralgia Pain study is aimed to determine the cause of TN in both humans and animals. The hypothesis is that there are areas of the brain and spinal cord that are a signature center of activity and the study uses magnetic resonance imaging (MRI) machines and other imaging measurements to measure brain activity before and after pain. Finding similar regions of neural activity will allow investigators to study new treatments and cures for the disease.

 

Study Information

 

The study will perform transcranial electrical brain stimulation on patients who meet the inclusion criteria with electrodes in salt-water soaked sponges attached to the head or smaller gel-covered disk electrodes that fit inside of an EEG cap. A weak direct or alternating current will be passed through the electrodes and the entire stimulation should last 20-30 minutes.

 

Inclusion Criteria

 

  • Healthy subjects who have been diagnosed with trigeminal neuralgia (TN) pain (ASA status 1, 2, or 3)
  • Subjects diagnosed with TN pain must have average pain in the moderate to severe (Visual Analog Scale (VAS) of 30-100 mm) range. Must be willing to stop current medications for 24 hours prior to their scan.
  • Diagnosed with classical trigeminal neuralgia, type 1 [TN1, G50.00], or symptomatic trigeminal neuralgia [TN2, G53.80] according to the International Classification of Headache (IHS) Disorders criteria (7)

 

Exclusion Criteria

 

  • Post-herpetic neuralgia, trigeminal neuropathic pain, and trigeminal deafferentation pain.
  • ASA status 4-5 and Emergency operation
  • Chronic disease (e.g. cardiovascular disease, liver disease, kidney disease, diabetes, etc.) other than trigeminal neuralgia
  • Pregnant subjects

 

Location

 

UF Health Shands Hospital

Gainesville, Florida, United States, 32610

McKnight Brain Institute

Gainesville, Florida, United States, 32611

 

Sponsors/Collaborators

 

University of Florida

Facial Pain Research Foundation

Contact: Janice R Braddy, BS, CCRC: (352) 273-6669

jbraddy@dental.ufl.edu

Contact/Principal Investigator: John K Neubert, DDS, PhD: (352) 273-5687

jneubert@dental.ufl.edu

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