The Neurophysiologic Signatures of Trigeminal Neuralgia Pain study is aimed to determine the cause of TN in both humans and animals. The hypothesis is that there are areas of the brain and spinal cord that are a signature center of activity and the study uses magnetic resonance imaging (MRI) machines and other imaging measurements to measure brain activity before and after pain. Finding similar regions of neural activity will allow investigators to study new treatments and cures for the disease.
The study will perform transcranial electrical brain stimulation on patients who meet the inclusion criteria with electrodes in salt-water soaked sponges attached to the head or smaller gel-covered disk electrodes that fit inside of an EEG cap. A weak direct or alternating current will be passed through the electrodes and the entire stimulation should last 20-30 minutes.
- Healthy subjects who have been diagnosed with trigeminal neuralgia (TN) pain (ASA status 1, 2, or 3)
- Subjects diagnosed with TN pain must have average pain in the moderate to severe (Visual Analog Scale (VAS) of 30-100 mm) range. Must be willing to stop current medications for 24 hours prior to their scan.
- Diagnosed with classical trigeminal neuralgia, type 1 [TN1, G50.00], or symptomatic trigeminal neuralgia [TN2, G53.80] according to the International Classification of Headache (IHS) Disorders criteria (7)
- Post-herpetic neuralgia, trigeminal neuropathic pain, and trigeminal deafferentation pain.
- ASA status 4-5 and Emergency operation
- Chronic disease (e.g. cardiovascular disease, liver disease, kidney disease, diabetes, etc.) other than trigeminal neuralgia
- Pregnant subjects
UF Health Shands Hospital
Gainesville, Florida, United States, 32610
McKnight Brain Institute
Gainesville, Florida, United States, 32611
University of Florida
Facial Pain Research Foundation
Contact: Janice R Braddy, BS, CCRC: (352) 273-6669
Contact/Principal Investigator: John K Neubert, DDS, PhD: (352) 273-5687
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